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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
TCPA_HUMAN
USC-OGP 2-DE database
:
TCPA_HUMAN
TCPA_HUMAN
General information about the entry
View entry in simple text format
Entry name
TCPA_HUMAN
Primary accession number
P17987
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=T-complex protein 1 subunit alpha; Short=TCP-1-alpha; AltName: Full=CCT-alpha;.
Gene name
Name=TCP1
Synonyms=CCT1, CCTA
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-7
{PLATELET 4-7}
Homo sapiens (Human)
map experimental info
PLATELET_4-7
MAP LOCATIONS:
SPOT OGP-0337
:
pI=5.60; Mw=60151
SPOT OGP-0339
:
pI=5.71; Mw=59965
PLATELET_5-6
{PLATELET 5-6}
Homo sapiens (Human)
map experimental info
PLATELET_5-6
MAP LOCATIONS:
SPOT OGP-0650
:
pI=5.71; Mw=58284
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1135
:
pI=5.94; Mw=63519
Cross-references
UniProtKB/Swiss-Prot
P17987; TCPA_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
TCPA_HUMAN
Primary accession number
P17987
Secondary accession number(s)
E1P5B2 Q15556 Q5TCM3
Sequence was last modified on
November 1, 1990 (version 1)
Annotations were last modified on
March 15, 2017 (version 183)
Name and origin of the protein
Description
RecName: Full=T-complex protein 1 subunit alpha; Short=TCP-1-alpha; AltName: Full=CCT-alpha;
Gene name
Name=TCP1
Synonyms=CCT1, CCTA
Encoded on
Name=TCP1; Synonyms=CCT1, CCTA
Keywords
Acetylation
;
ATP-binding
;
Chaperone
;
Complete proteome
;
Cytoplasm
;
Cytoskeleton
;
Direct protein sequencing
;
Nucleotide-binding
;
Phosphoprotein
;
Polymorphism
;
Reference proteome
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
X52882; CAA37064.1
; -; mRNA
EMBL
BT006969; AAP35615.1
; -; mRNA
EMBL
AL135914; CAI21851.1
; -; Genomic_DNA
EMBL
CH471051; EAW47616.1
; -; Genomic_DNA
EMBL
CH471051; EAW47618.1
; -; Genomic_DNA
EMBL
BC000665; AAH00665.1
; -; mRNA
EMBL
M26885; AAA61059.1
; -; Genomic_DNA
EMBL
M27272; AAA61060.1
; -; Genomic_DNA
EMBL
M26889; AAA61060.1
; JOINED; Genomic_DNA
CCDS
CCDS5269.1; -
; .
PIR
S10486; S10486
; .
RefSeq
NP_110379.2; NM_030752.2
; .
UniGene
Hs.363137; -
; .
ProteinModelPortal
P17987; -
; .
SMR
P17987; -
; .
BioGrid
112810; 207
; .
DIP
DIP-33676N; -
; .
IntAct
P17987; 128
; .
MINT
MINT-4999235; -
; .
STRING
9606.ENSP00000317334; -
; .
iPTMnet
P17987; -
; .
PhosphoSitePlus
P17987; -
; .
SwissPalm
P17987; -
; .
BioMuta
TCP1; -
; .
DMDM
135538; -
; .
OGP
P17987; -
; .
REPRODUCTION-2DPAGE
IPI00290566; -
; .
REPRODUCTION-2DPAGE
P17987; -
; .
UCD-2DPAGE
P17987; -
; .
EPD
P17987; -
; .
MaxQB
P17987; -
; .
PaxDb
P17987; -
; .
PeptideAtlas
P17987; -
; .
PRIDE
P17987; -
; .
DNASU
6950; -
; .
Ensembl
ENST00000321394; ENSP00000317334
; ENSG00000120438; .
GeneID
6950; -
; .
KEGG
hsa:6950; -
; .
UCSC
uc003qsr.4; human
; .
CTD
6950; -
; .
DisGeNET
6950; -
; .
GeneCards
TCP1; -
; .
HGNC
HGNC:11655; TCP1
; .
HPA
CAB017460; -
; .
HPA
HPA027337; -
; .
HPA
HPA031082; -
; .
MIM
186980; gene
; .
neXtProt
NX_P17987; -
; .
OpenTargets
ENSG00000120438; -
; .
PharmGKB
PA36406; -
; .
eggNOG
KOG0360; Eukaryota
; .
eggNOG
COG0459; LUCA
; .
GeneTree
ENSGT00550000074878; -
; .
HOGENOM
HOG000226729; -
; .
HOVERGEN
HBG001052; -
; .
InParanoid
P17987; -
; .
KO
K09493; -
; .
OMA
HYLAQEG; -
; .
OrthoDB
EOG091G04HL; -
; .
PhylomeDB
P17987; -
; .
TreeFam
TF106331; -
; .
Reactome
R-HSA-389957; Prefoldin mediated transfer of substrate to CCT/TriC
; .
Reactome
R-HSA-389960; Formation of tubulin folding intermediates by CCT/TriC
; .
Reactome
R-HSA-390450; Folding of actin by CCT/TriC
; .
Reactome
R-HSA-390471; Association of TriC/CCT with target proteins during biosynthesis
; .
Reactome
R-HSA-5620922; BBSome-mediated cargo-targeting to cilium
; .
Reactome
R-HSA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
; .
ChiTaRS
TCP1; human
; .
GeneWiki
T-complex_1; -
; .
GenomeRNAi
6950; -
; .
PRO
PR:P17987; -
; .
Proteomes
UP000005640; Chromosome 6
; .
Bgee
ENSG00000120438; -
; .
CleanEx
HS_TCP1; -
; .
ExpressionAtlas
P17987; baseline and differential
; .
Genevisible
P17987; HS
; .
GO
GO:0001669; C:acrosomal vesicle
; IEA:Ensembl; .
GO
GO:0044297; C:cell body
; IEA:Ensembl; .
GO
GO:0005813; C:centrosome
; IDA:MGI; .
GO
GO:0005832; C:chaperonin-containing T-complex
; IDA:UniProtKB; .
GO
GO:0005829; C:cytosol
; TAS:Reactome; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005794; C:Golgi apparatus
; IEA:Ensembl; .
GO
GO:0005874; C:microtubule
; IDA:UniProtKB; .
GO
GO:0043209; C:myelin sheath
; IEA:Ensembl; .
GO
GO:0005720; C:nuclear heterochromatin
; IEA:Ensembl; .
GO
GO:0000242; C:pericentriolar material
; IEA:Ensembl; .
GO
GO:0002199; C:zona pellucida receptor complex
; IEA:Ensembl; .
GO
GO:0005524; F:ATP binding
; IEA:UniProtKB-KW; .
GO
GO:0044183; F:protein binding involved in protein folding
; IBA:GO_Central; .
GO
GO:0003723; F:RNA binding
; IDA:UniProtKB; .
GO
GO:0031625; F:ubiquitin protein ligase binding
; IPI:ParkinsonsUK-UCL; .
GO
GO:0051082; F:unfolded protein binding
; IBA:GO_Central; .
GO
GO:0006458; P:'de novo' protein folding
; IBA:GO_Central; .
GO
GO:0007339; P:binding of sperm to zona pellucida
; IEA:Ensembl; .
GO
GO:0061077; P:chaperone-mediated protein folding
; IBA:GO_Central; .
GO
GO:1904851; P:positive regulation of establishment of protein localization to telomere
; IMP:BHF-UCL; .
GO
GO:1904871; P:positive regulation of protein localization to Cajal body
; IMP:BHF-UCL; .
GO
GO:0051973; P:positive regulation of telomerase activity
; IMP:BHF-UCL; .
GO
GO:1904874; P:positive regulation of telomerase RNA localization to Cajal body
; IMP:BHF-UCL; .
GO
GO:0032212; P:positive regulation of telomere maintenance via telomerase
; IMP:BHF-UCL; .
GO
GO:0006457; P:protein folding
; TAS:Reactome; .
GO
GO:0050821; P:protein stabilization
; IMP:BHF-UCL; .
GO
GO:2000109; P:regulation of macrophage apoptotic process
; IEA:Ensembl; .
GO
GO:0090666; P:scaRNA localization to Cajal body
; IMP:BHF-UCL; .
GO
GO:1901998; P:toxin transport
; IEA:Ensembl; .
GO
GO:0044053; P:translocation of peptides or proteins into host cell cytoplasm
; IEA:Ensembl; .
GO
GO:0007021; P:tubulin complex assembly
; NAS:UniProtKB; .
CDD
cd03335; TCP1_alpha
; 1; .
Gene3D
1.10.560.10; -
; 2; .
Gene3D
3.30.260.10; -
; 2; .
Gene3D
3.50.7.10; -
; 1; .
InterPro
IPR012715; Chap_CCT_alpha
; .
InterPro
IPR017998; Chaperone_TCP-1
; .
InterPro
IPR002194; Chaperonin_TCP-1_CS
; .
InterPro
IPR002423; Cpn60/TCP-1
; .
InterPro
IPR027409; GroEL-like_apical_dom
; .
InterPro
IPR027413; GROEL-like_equatorial
; .
InterPro
IPR027410; TCP-1-like_intermed
; .
PANTHER
PTHR11353:SF145; PTHR11353:SF145
; 1; .
Pfam
PF00118; Cpn60_TCP1
; 1; .
PRINTS
PR00304; TCOMPLEXTCP1
; .
SUPFAM
SSF52029; SSF52029
; 1; .
TIGRFAMs
TIGR02340; chap_CCT_alpha
; 1; .
PROSITE
PS00750; TCP1_1
; 1; .
PROSITE
PS00751; TCP1_2
; 1; .
PROSITE
PS00995; TCP1_3
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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